杜文静，1981年生，籍贯山东，永利集团3044官网欢迎您基础医学研究所教授，博士生导师。1999年考入山东师范大学生命科学专业，2003年获得学士学位。2003年-2008年在中国科学技术大学细胞生物学专业攻读博士学位，从事细胞凋亡研究。2008年-2015年美国宾夕法尼亚大学医学院肿瘤生物系进行博士后研究和研究助理工作，主要研究肿瘤代谢重塑的调控机制。2016年起在基础医学研究所细胞生物学系担任课题组长。

代谢与肿瘤等重大疾病的发生和治疗。利用细胞、生化、分子生物学手段和小鼠模型来探索重大疾病如肿瘤等发生异常改变的代谢途径；研究代谢重塑的核心机制；揭示代谢在重大疾病发生发展中的重要功能。主要研究方向：代谢物的感知与功能研究；代谢通路（酶）的新功能探索。

1. Yao Pengbo#, Chen Taiqi#, Jiang Peng, Li Li, Du Wenjing*. Functional skewing of TRIM21-SIRT5 interplay dictates IL-1β production in DSS-induced colitis. EMBO Rep. 2022 Jun 30:e54391. (IF=9.071)

2. Zhao Mengjia#, Yao Pengbo#, Mao Youxiang#, Wu jinjun#, Wang Weihua, Geng Chenhui, Cheng Jie, Du Wenjing*, Jiang Peng*. Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydrooxyglutarate. Nat Metab, 2022 Feb;4(2):225-238. (IF=19.8651)

3. Li Wei#, Kou Junjie#, Qin Junying#, Li Li, Zhang Zhenxi, Pan Ying, Xue Yi*, Du Wenjing*. NADPH levels affect cellular epigenetic state by inhibiting HDAC3-Ncor complex. Nat Metab, 2021, 3(1):75-89. (IF=19.8651)

4. Sun Huishan#, Li Li#, Li Wei#, Yang Fan, Zhang Zhenxi, Liu Zizhao, Du Wenjing*. p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth. EMBO Rep, 2021, Oct 5;22(10):e52537. (IF=9.071)

5. Zhao Mengjia#; Jiang Peng; Du Wenjing*. MYC retards cancer cell migration through suppressing fibronectin expression, Sci Bull, 2019, 64(11): 715-717. (IF=9.5106)

6. Li Le#, Li Lijia#, Li Wei, Chen Taiqi, Bin Zou, Zhao Lina, Wang Huili, Wang Xueying, Xu, Lina, Liu, Xiaohui, Wang Dong, Li Bo, Mak Tak W, Du Wenjing*, Yang Xiaolu*, Jiang Peng*. TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation., Nat Commun, 2018, 9(1): 4683-4683. (IF= 11.878)

7. Yao Pengbo#, Sun Huishan, Xu Chang, Chen Taiqi, Zou Bing, Jiang Peng*, Du Wenjing*. Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions, J Biol Chem, 2017, 292(41): 17113-17120. (IF=4.011)

8. Du Wenjing#, Jiang Peng#, Mancuso Anthony, Stonestrom Aaron, Brewer Michael D, Minn Andy J, Mak Tak W, Wu Mian*, Yang Xiaolu*. TAp73 enhances the pentose phosphate pathway and supports cell proliferation., Nat Cell Biol, 2013, 15(8): 991-1000. (IF=20.058, C100)

9. Jiang Peng#, Du Wenjing#, Wang Xingwu, Mancuso Anthony, Gao Xiang, Wu Mian*, Yang Xiaolu*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase., Nat Cell Biol, 2011, 13(3): 310-316. (IF= 19.488, C100, F1000)

10. Jiang Peng#, Du Wenjing#, Mancuso Anthony, Wellen Kathryn E, Yang Xiaolu*. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence., Nature, 2013, 493(7434): 689-693. (IF= 42.351, C100, F1000)