高亦博，1984年生，籍贯辽宁海城，国家自然科学基金委优青，国家重点研发计划首席科学家。现为国家癌症中心/国家恶性肿瘤临床医学研究中心/永利集团3044官网欢迎您肿瘤医院转化医学实验室主任，博士生导师；胸外科主治医师、副研究员、实验室主管。清华大学、永利集团3044官网欢迎您临床医学、肿瘤学博士，美国杜克大学医学中心访问学者。

主要开展食管癌、肺癌等胸部肿瘤的基因组测序、表观遗传、多组学分子分型和精准医学研究，探究表观遗传和代谢重编程调控癌症发生发展和疗效预后的分子机制，筛选和验证肿瘤精准诊疗生物标志物。

1. Zhou X#, Yao Z#, Bai H, Duan J, Wang Z, Wang X, Zhang X, Xu J, Fei K, Zhang Z, Tan F, Xue Q, Gao S, Gao Y*, Wang J*, He J*. Treatment-related adverse events of PD-1 and PD-L1 inhibitor-based combination therapies in clinical trials: a systematic review and meta-analysis. Lancet Oncology. 2021, 22(9):1265-1274. (IF=54.433)

2. Li R#, Yang Z, Shao F, Cheng H, Wen Y, Sun S, Guo W, Li Z, Zhang F, Xue L, Bi N, Wang J, Sun Y, Li Y, Tan F, Xue Q, Gao S, Shi S*, Gao Y*, He J*. Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes. Nature Communications. 2021, 12(1):3785. (IF=17.694)

3. Yang X#, Shao F, Guo D, Wang W, Wang J, Zhu R, Gao Y*, He J*, Lu Z*. WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis. Cell Death & Disease. 2021, 12(5):462. (IF=9.685)

4. Wang W#, Shao F#, Yang X, Wang J, Zhu R, Yang Y, Zhao G, Guo D, Sun Y, Wang J, Xue Q, Gao S, Gao Y*, He J*, Lu Z*. METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding. Nature Communications. 2021, 12(1):3803. (IF=17.694)

5. Shao F#, Bian X#, Jiang H, Zhao G, Zhu L, Xu D, Wang S, Guo W, Xing D, Xue Q, Gao Y*, He J*, Lu Z*. Association of phosphoenolpyruvate carboxykinase 1 protein kinase activity-dependent sterol regulatory element-binding protein 1 activation with prognosis of oesophageal carcinoma. European Journal of Cancer. 2021, 142:123-131. (IF= 10.002)

6. Zhang H#, Guo W, Zhang F, Li R, Zhou Y, Shao F, Feng X, Tan F, Wang J, Gao S, Gao Y*, He J*. Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma. Frontiers in Oncology. 2020, 10:559568. (IF=6.244)

7. Yang Z#, Xu J, Li L, Li R, Wang Y, Tian Y, Guo W, Wang Z, Tan F, Ying J, Jiao Y, Gao S*, Wang J*, Gao Y*, He J*. Integrated molecular characterization reveals potential therapeutic strategies for pulmonary sarcomatoid carcinoma. Nature Communications. 2020, 11(1):4878. (IF=14.919)

8. Shao F#, Yang X, Wang W, Wang J, Guo W, Feng X, Shi S, Xue Q, Gao S, Gao Y*, Lu Z*, He J*. Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysis. Cancer Communications. 2019, 39(1):54. (IF=5.627)

9. Wang C#, Li Z, Shao F, Yang X, Feng X, Shi S, Gao Y*, He J*. High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation. Journal of Experimental & Clinical Cancer Research. 2017, 36(1):84. (IF=6.217)

10. Gao YB#, Chen ZL, Li JG, Hu XD, Shi XJ, Sun ZM, Zhang F, Zhao ZR, Li ZT, Liu ZY, Zhao YD, Sun J, Zhou CC, Yao R, Wang SY, Wang P, Sun N, Zhang BH, Dong JS, Yu Y, Luo M, Feng XL, Shi SS, Zhou F, Tan FW, Qiu B, Li N, Shao K, Zhang LJ, Zhang LJ, Xue Q, Gao SG, He J*. Genetic landscape of esophageal squamous cell carcinoma. Nature Genetics. 2014, 46(10):1097-102. (IF=29.352, C100)