贺海燕，1985年生，籍贯陕西神木，微生物学家，医药生物技术研究所研究员，博士生导师。2003年考入天津大学应用化学专业，2007年获得学士学位。2007年起在中国科学院大学生命有机化学专业硕博连读，攻读博士学位，从事天然产物化学生物学研究。2014年起进入加拿大英属哥伦比亚大学化学系进行博士后研究工作，主要研究方向为天然产物生物合成及生物催化。2021年3月加入医药生物技术研究所任研究员。

以酶元件为基础，利用合成生物学、组合生物合成和代谢工程等方法，优化或设计重构临床药物生物制备途径；利用理性设计、同源蛋白筛选及定向进化等方法，开发具有特定功能的生物催化剂，高效制备药物合成中间体。

1. Hai-Yan He*, Haruka Niikura, Yi-Ling Du, Katherine S. Ryan*. Synthetic and biosynthetic routes to nitrogen-nitrogen bonds. Chemical Society Reviews 2022, 51, 2991-3046.

2. Hai-Yan He, and Katherine S. Ryan*. Glycine-derived Nitronates Bifurcate Between O-Methylation and Denitrification in Bacteria. Nature Chemistry 2021, 13, 599-606.

3. Hai-Yan He, Alyssa C. Henderson, Yi-Ling Du, and Katherine S. Ryan*. Two-Enzyme Pathway Links L-Arginine to Nitric Oxide in N-Nitroso Biosynthesis. J. Am. Chem. Soc. 2019, 141, 4026–4033.

4. Hai-Yan He, Man-Cheng Tang, Feng Zhang, and Gong-Li Tang*. Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis. J. Am. Chem. Soc. 2014, 136, 4488–4491.

5. Hai-Yan He, Hua Yuan, Man-Cheng Tang, and Gong-Li Tang*. An Unusual Dehydratase Acting on Glycerate and a Ketoreductase Stereoselectively Reducing a-Ketone in Polyketide Starter Unit Biosynthesis. Angew. Chem. Int. Ed. 2014, 53, 11315 –11319.

6. Long-Fei Wu^#, Hai-Yan He^#, Hai-Xue Pan, Li Han, Renxiao Wang, and Gong-Li Tang. Characterization of QmnD3/QmnD4 for double bond formation in quartromicin biosynthesis. Org. Lett. 2014, 16, 1578-81.

7. Hai-Yan He^#, Hai‐Xue Pan^#, Long‐Fei Wu, Bei‐Bei Zhang, Han‐Bo Chai, Wen Liu, and Gong‐Li Tang*. Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line. Chemistry & Biology 2012, 19, 1313–1323.