陈东升，1988年生，籍贯湖北十堰，系统医学研究院研究员，博士生导师。2006年考入华中农业大学生物学基地班，2010年获学士学位，2013年获得硕士学位，2017年获得英国剑桥大学遗传学专业博士学位。2017年7月进入华大基因学院进行博士后研究工作，主要利用单细胞测序技术和空间转录组测序技术对出生缺陷疾病、神经退行性疾病和免疫系统疾病展开了一系列研究。

课题组结合基因组大数据、生物信息学方法及单细胞测序、空间转录组测序等高通量实验技术，解析个体发育和复杂疾病发生的分子调控机理，筛选感染性疾病和恶性肿瘤的药物靶标。

1. Linlin Zhang#, Dongsheng Chen#, Dongli Song#, Xiaoxia Liu, Yanan Zhang, Xun Xu* & Xiangdong Wang*. “Clinical and translational values of spatial transcriptomics” Signal Transduction and Targeted Therapy, 2022 Apr 1;7(1):111. (IF=18.187)

2. Zhibin Li#, Chengcheng Sun#, Fei Wang#, Xiran Wang#, Jiacheng Zhu, Lihua Luo, Xiangning Ding2, Yanan Zhang, Peiwen Ding, Haoyu Wang, Mingyi Pu, Zhihua Ou, Yuejiao Li, Shiyou Wang, Qiuyu Qin, Yanan Wei, Jian Sun, Xiangdong Wang, Yonglun Luo, Dongsheng Chen*, Wei Qiu*. “Single-cell transcriptomic insights into molecular mechanisms governing immune cell heterogeneity across different species” Clinical and Translational Medicine, 2022 Jan;12(1):e689. (IF= 11.492)

3. Dongsheng Chen#, Jian Sun#, Jiacheng Zhu#, Xiangning Ding#, Tianming Lan#, Xiran Wang#, Weiying Wu, Zhihua Ou, Linnan Zhu, Peiwen Ding, Haoyu Wang, Lihua Luo, Rong Xiang, Xiaoling Wang, Jiaying Qiu, Shiyou Wang, Haimeng Li, Chaochao Chai,Langchao Liang, Fuyu An, Le Zhang, Lei Han, Yixin Zhu, Feiyue Wang, Yuting Yuan, Wendi Wu, Chengcheng Sun, Haorong Lu, Jihong Wu,, Xinghuai Sun,, Shenghai Zhang,, Sunil Kumar Sahu, Ping Liu, Jun Xia, Lijing Zhang, Haixia Chen, Dongming Fang, Yuying Zeng, Yiquan Wu, Zehua Cui, Qian He, Sanjie Jiang, Xiaoyan Ma, Weimin Feng, Yan Xu, Fang Li, Zhongmin Liu, Lei Chen, Fang Chen, Xin Jin, Wei Qiu, Tianjiao Wang, Yang Li, Xiumei Xing, Huanming Yang, Yanchun Xu,Yan Hua*, Yahong Liu*, Huan Liu*, Xun Xu*. “Single cell atlas for 11 non-model mammals, reptiles and birds” Nature Communications, 2021 Dec 6;12(1):7083. (IF=14.919)

4. Dongsheng Chen#, Cong Tan#, Peiwen Ding#, Lihua Luo#, Jiacheng Zhu#, Xiaosen Jiang#, Zhihua Ou, Xiangning Ding, Tianming Lan, Yixin Zhu, Yi Jia, Yanan Wei, Runchu Li, Qiuyu Qin, Chengcheng Sun, Wandong Zhao, Zhiyuan Lv, Haoyu Wang, Wendi Wu, Yuting Yuan, Mingyi Pu, Yuejiao Li, Yanan Zhang, Ashley Chang, Guoji Guo, Yong Bai*, Xin Jin*, Huan Liu*. “VThunter: a database for single-cell screening of virus target cells in animal kingdom”. Nucleic Acids Research, 2021 Oct 11;gkab894. (IF=16.971)

5. Peng Wu#, Dongsheng Chen#, Wencheng Ding#, Ping Wu#, Hongyan Hou#, Yong Bai#, Yuwen Zhou#, Kezhen Li#, Shunian Xiang, Panhong Liu, Jia Ju, Ensong Guo, Jia Liu, Bin Yang, Junpeng Fan, Liang He, Ziyong Sun, Ling Feng, Jian Wang, Tangchun Wu, Hao Wang, Jin Cheng, Hui Xing, Yifan Meng, Yongsheng Li, Yuanliang Zhang, Hongbo Luo, Gang Xie, Xianmei Lan, Ye Tao, Jiafeng Li, Hao Yuan, Kang Huang, Wan Sun, Xiaobo Qian, Zhichao Li, Mingxi Huang, Peiwen Ding, Haoyu Wang, Jiaying Qiu, Feiyue Wang, Shiyou Wang, Jiacheng Zhu, Xiangning Ding, Chaochao Chai, Langchao Liang, Xiaoling Wang, Lihua Luo, Yuzhe Sun, Ying Yang, Zhenkun Zhuang, Tao Li, Lei Tian, Shaoqiao Zhang, Linnan Zhu, Ashley Chang, Lei Chen, Yiquan Wu, Xiaoyan Ma, Fang Chen, Yan Ren, Xun Xu, Siqi Liu, Jian Wang, Huanming Yang, Lin Wang, Chaoyang Sun*, Ding Ma*, Xin Jin*, and Gang Chen*. 2021. “The Trans-Omics Landscape of COVID-19.” Nature Communications 12(1):1–16. (IF=14.919)

6. Jiacheng Zhu#, Fang Chen#, Lihua Luo#, Weiying Wu#, Jinxia Dai#, Jixing Zhong, Xiumei Lin, Chaochao Chai, Peiwen Ding, Langchao Liang, Shiyou Wang, Xiangning Ding, Yin Chen, Haoyu Wang, Jiaying Qiu, Feiyue Wang, Chengcheng Sun, Yuying Zeng, Jian Fang, Xiaosen Jiang, Ping Liu, Gen Tang, Xin Qiu, Xingliang Zhang, Yetian Ruan, Sanjie Jiang, Jiankang Li, Shida Zhu, Xun Xu, Fang Li, Zhongmin Liu, Gang Cao*, and Dongsheng Chen*. 2021. “Single-Cell Atlas of Domestic Pig Cerebral Cortex and Hypothalamus.” Science Bulletin 66(14):1448–61. (Cover Story) (IF=11.78)

7. Jixing Zhong#, Gen Tang#, Jiacheng Zhu#, Weiying Wu#, Ge Li#, Xiumei Lin, Langchao Liang, Chaochao Chai, Yuying Zeng, Feiyue Wang, Lihua Luo, Jiankang Li, Fang Chen, Zhen Huang, Xiuqing Zhang, Yu Zhang, Hongde Liu, Xin Qiu*, Shengping Tang*, and Dongsheng Chen*. 2021. “Single-Cell Brain Atlas of Parkinson’s Disease Mouse Model.” Journal of Genetics and Genomics 48(4):277–88. (Cover Story) (IF=4.275)

8. Lijing Zhang#, Jiacheng Zhu#, Haoyu Wang#, Jun Xia, Ping Liu, Fang Chen, Hui Jiang, Qiuling Miao, Weiying Wu, Lingli Zhang, Lihua Luo, Xiaosen Jiang, Yong Bai, Chengcheng Sun, Dongsheng Chen*, and Xingliang Zhang*. 2021. “A High-Resolution Cell Atlas of the Domestic Pig Lung and an Online Platform for Exploring Lung Single-Cell Data.” Journal of Genetics and Genomics 48(5):411–25. (IF=4.275)