单强，1983年生，籍贯河南，系统医学研究院研究员，博士生导师。2002年考入河南师范大学生物技术专业，2006年获学士学位。2006-2013年在中科院北京基因组研究所生化与分子生物学专业硕博连读。2013-2022年起先后在美国哈佛大学布列根和妇女医院、爱荷华大学微生物和免疫学系、哈肯萨克子午线医学院发现与创新中心以博士后、助理研究院身份进行科研工作。主要研究研究CD8+ T细胞不同谱系的建立、维持机制。2022年加入系统医学研究院，任职研究员。

通过感染免疫、肿瘤免疫等模型，利用转录组、ATAC-seq、ChIP-seq以及单细胞测序等手段，研究CD8+ T细胞不同谱系的建立、维持机制。结合新型基因编辑技术和细胞治疗策略，靶向调控不同的亚群分化，为免疫治疗提供新靶点和方案。

1. Qiang Shan#, Shaoqi Zhu#, Xia Chen, Jia Liu, Shuang Yuan, Xiang Li, Weiqun Peng*, Hai-Hui Xue*; Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8⁺ T cell homeostasis., Nat Immunol. 2022, 23(8):1222-1235. (IF: 25.6)

2. Qiang Shan#, Sheng'en Hu#, Xia Chen, Zhouhao Zeng, Shaoqi Zhu, Weiqun Peng*, Hai-Hui Xue*. Tcf1 preprograms glycolysis mobilization in central memory CD8⁺ T cells in recall response. Nat Immunol, 2022, 23(3): 386-398. (IF: 25.6)

3. Qiang Shan#, Xiang Li#, Xia Chen, Zhouhao Zeng, Shaoqi Zhu, Kexin Gai, Weiqun Peng*, Hai-Hui Xue*. Tcf1 and Lef1 provide constant supervision to mature CD8⁺ T cell identity and function by organizing genomic architecture. Nat Commun. 2021 Oct 6;12(1):5863 (IF: 14.9)

4. Qiang Shan#, Sheng'en Hu#, Xia Chen, Derek B Danahy, Vladimir P Badovinac, Chongzhi Zang*, Hai-Hui Xue*. Ectopic Tcf1 Expression Instills a Stem-Like Program in Exhausted CD8⁺ T Cells to Enhance Viral and Tumor Immunity. Cell Mol Immunol. 2021 May;18(5):1262-1277. (IF: 11.5)

5. Qiang Shan#, Zhouhao Zeng#, Shaojun Xing, Fengyin Li, Stacey M Hartwig, Jodi A Gullicksrud, Samarchith P Kurup, Natalija Van Braeckel-Budimir, Yao Su, Matthew D Martin, Steven M Varga, Ichiro Taniuchi, John T Harty, Weiqun Peng*, Vladimir P Badovinac, Hai-Hui Xue*. The transcription factor Runx3 guards cytotoxic CD8⁺ effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol. 2017 Aug;18(8):931-939. (F1000) (IF: 21.8)

6. Qiang Shan #, Markryan Dwyer, Samir Rahman, Mihaela Gadjeva. Distinct susceptibilities of corneal P. aeruginosa clinical isolates to Neutrophil Extracellular Trap-mediated immunity. Infect Immun. 2014 Oct;82(10):4135-43. (IF: 2.4)