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生物医学工程研究所

个人简介

杨菁,生物医学工程研究所研究员,生物医学工程、药剂学双专业博导。本科毕业于南京化工大学高分子化工专业,获学士学位。2001年获得中国协和医科大学生物医学工程专业硕士学位。博士就读于清华大学医学部永利集团3044官网欢迎您生物医学工程专业,获博士学位。从事生物医用材料与药物缓控释系统在血管再生与修复方向的研究。2007年升为副研究员,2012年晋升为研究员。


主要研究方向

针对心血管疾病的临床治疗需求,结合生物医用材料的设计与药物缓控释系统的构建,从事血管再生与修复方向的基础应用研究。


代表性成果

1. Huiyang Li, Xiaoyu Liang, Youlu Chen, Kaijing Liu, Xue Fu, Chuangnian Zhang*, Xiaoli Wang, Jing Yang*. Synergy of antioxidant and M2 polarization in polyphenol-modified konjac glucomannan dressing for remodeling wound. Bioeng. Transl. Med. 2022, e10398. (IF=10.6843)

2. Xu R, Liu K, Wang X, Zhang C, Zhang Y, Yang J. In situ release of IL-2/IL-12 from SiO2-engineered dendritic cells for synergistic immunotherapy. Nanoscale 2022,11;14(31): 11235-11251. (IF=8.3075)

3. Youlu Chen#, Zuoguan Chen#, Jianwei Duan , Liang Gui , Huiyang Li , Xiaoyu Liang , Xinxin Tian , Kaijing Liu , Yongjun Li*, Jing Yang*. H2O2-responsive VEGF/NGF gene co-delivery nano-system achieves stable vascularization in ischemic hindlimbs. Journal of Nanobiotechnology 2022, 20:145.IF=9.4287

4. Xiaoyu Liang#, Huiyang Li#, Xuanling Li, Xinxin Tian, Aiai Zhang, Qingzhi Luo, Jianwei Duan, Youlu Chen, Liyun Pang, Chen Li, Xingjie Liang, Yong ZengJing Yang*. Highly sensitive H2O2 scavenging nano-bionic system for precise treatment of atherosclerosis, Acta Pharm. Sin. B 2022. (IF =14.9033)

5. Liang Gui#, Youlu Chen#, Yongpeng Diao, Zuoguan Chen, Jianwei Duan, Xiaoyu Liang Huiyang Li, Kaijing Liu, Yuqing Miao, Qing Gao, Zhichao Li, Jing Yang*, Yongjun Li*. ROS-responsive nanoparticle-mediated delivery of CYP2J2 gene for therapeutic angiogenesis in severe hindlimb ischemia. Mater. Today Bio. 2022,13:100192. (IF=10.7617).

6. Youlu Chen#, Yong Zeng#, Xiaowei Zhu, Lifu Miao, Xiaoyu Liang, Jianwei Duan, Huiyang Li, Xinxin Tian, Liyun Pang, Yongxiang Wei*, Jing Yang*. Significant difference between sirolimus and paclitaxel nanoparticles in anti-proliferation effect in normoxia and hypoxia: The basis of better selection of atherosclerosis treatment. Bioactive Materials 2021, 6(3):880-889. (IF=16.8737)

7. Zuoguan Chen#, Jianwei Duan#, Yongpeng Diao, Youlu Chen, Xiaoyu Liang, Huiyang Li, Yuqing Miao, Qing Gao, Liang Gui, Xiaoli Wang, Jing Yang∗, Yongjun Li∗. ROS-responsive capsules engineered from EGCG-Zinc networks improve therapeutic angiogenesis in mouse limb ischemia. Bioactive Materials. 2021,6(1):1-11. (IF=16.8737)

8. Jianwei Duan#, Zuoguan Chen#, Xiaoyu Liang, Youlu Chen, Huiyang Li, Xinxin Tian, Mingming Zhang, Xiaoli Wang*, Hongfan Sun, Deling Kong, Yongjun Li*, Jing Yang*. Construction and application of therapeutic metal-polyphenol capsule for peripheral artery disease. Biomaterials. 2020, 255: 120199. (IF=12.479)

9. Xiaowei Zhu#, Hongzhi Xie#, Xiaoyu Liang, Xuanling Li, Jianwei Duan, Yongxia Chen, Ziying Yang, Chao Liu, Cuiwei Wang, Hailing Zhang, Quan Fang, Hongfan Sun, Chen Li, Yongjun Li, Chun Wang, Cunxian Song, Yong Zeng*, Jing Yang*. Bilayered nanoparticles with sequential release of VEGF gene and paclitaxel for restenosis inhibition in atherosclerosis. ACS Appl. Mater. Interfaces. 2017, 9: 27522-27532. (IF=8.097) 

10. Jing Yang#, Yong Zeng#, Chao Zhang, Yongxia Chen, Ziying Yang, Yongjun Li, Xigang Leng, Deling Kong, Xiaoqing Wei*, Hongfan Sun*, Cunxian Song*. The prevention of restenosis in vivo with a VEGF gene and paclitaxel co-eluting stent.  Biomaterials. 2013,34(6): 1635-1643. (IF=8.312)