杨沛然，1990年生，籍贯北京，从事呼吸系统疾病及肺血管病研究，基础医学研究所副研究员，博士生导师。2008年考入英国剑桥大学自然科学专业，2011年获得学士学位。2011年在剑桥大学生物医学专业攻读硕士学位，从事心血管及代谢疾病研究。2013年在剑桥大学生物医学专业攻读博士学位，从事肺血管病研究。2017年进入哈佛大学医学院进行博士后研究工作，主要研究肺动脉高压的发病机制研究及新药研发。2021年以“引进人才”加入基础医学研究所。

肺血管病变的发生机制与干预：探究不同类型肺动脉高压中血管病变的共有分子改变；构建肺血管病变的类器官及跨物种动物模型，开展靶向挖掘及药物筛选；利用干细胞及衍生物改善肺血管微环境，开展干预手段研究。

1. Yang P#, Bocobo GA, Yu PB*. Sotatercept for Pulmonary Arterial Hypertension. N Engl J Med 2021 385(1):92-93. (IF=91.3)

2. Yang P#, Yu PB*. Periostin: A Novel Integrator of Hypoxic Signaling in Pulmonary Hypertension. Circ Res. 2020 127(9):1153-1155. (IF=14.5)

3. Yang P#, Troncone L, Augur ZM, Kim SSJ, McNeil ME, Yu PB*. The role of bone morphogenetic protein signaling in vascular calcification. Bone. 2020 141:115542. (IF=4.1)

4. Yung LM#, Yang P#, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R, Yu PB*. ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension. Sci Transl Med. 2020 12(543):eaaz5660. (IF=16.3)

5. Yang P#, Read C#, Kuc RE, Nyimanu D, Williams TL, Crosby A, Buonincontri G, Southwood M, Sawiak SJ, Morrell NW, Davenport AP, Maguire JJ*. A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension. Br J Pharmacol. 2019 176(9):1206-1221. (IF=6.6)

6. Yang P#, Yu PB*. In Search of the Second Hit in Pulmonary Arterial Hypertension. Circ Res. 2019 124(1):6-8. (IF=15.9)

7. Yang P#, Read C, Kuc RE, Buonincontri G, Southwood M, Torella R, Upton PD, Crosby A, Sawiak SJ, Carpenter TA, Glen RC, Morrell NW, Maguire JJ*, Davenport AP*. Elabela/Toddler Is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension. Circulation. 2017 135(12):1160-1173. (IF=19.3, ESI)

8. Yang P#, Kuc RE, Brame AL, Dyson A, Singer M, Glen RC, Cheriyan J, Wilkinson IB, Davenport AP, Maguire JJ*. [Pyr1]Apelin(1-12) is a biologically active ACE2 metabolite of the endogenous cardiovascular peptide [Pyr1]Apelin-13. Front Neurosci. 2017 11:92. (IF=3.6)

9. Read C#, Fitzpatrick CM#, Yang P#, Kuc RE, Maguire JJ*, Glen RC*, Foster RE*, Davenport AP*. Cardiac action of the first G protein biased small molecule apelin agonist. Biochem Pharmacol. 2016 116:63-72. (IF=5.1)

10. Yang P#, Maguire JJ, Davenport AP*. Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 2015 36(9):560-567. (IF=11.5)