林东昕，1955年生，籍贯福建福州，肿瘤遗传学和基因组学专家，肿瘤医院研究员，博士生导师。1976年进入上海医科大学公共卫生专业，1980年毕业。1983年在北京医科大学公共卫生专业攻读硕士学位，从事食品卫生与毒理学研究。1988年在WHO国际癌症研究机构（法国里昂）从事肿瘤病因学研究。1990年进入美国国家毒理学研究中心作为高级访问学者进行研究工作，主要研究肿瘤病因和肿瘤分子流行病。1994年回国工作，1995年为副研究员/副教授，1997年为研究员/教授。2013年当选中国工程院院士。

主要研究我国常见恶性肿瘤（食管癌和胰腺癌等）基因组的遗传和表遗传学改变；这些改变与肿瘤发生发展及其表型的关系、在精准防治和早筛中的作用。

1.Deng S#, Zhang J#, Su J#, Zuo Z#, Zeng L, Liu K, Zheng Y, Huang X, Bai R, Zhuang L, Ye Y, Li M, Pan L, Deng J, Wu G, Li R, Zhang S, Wu C, Lin D*, Chen J*, Zheng J*. RNA m6A regulates transcription via DNA demethylation and chromatin accessibility. Nat Genet. 2022 Sep;54(9):1427-1437. (IF=41.307)

2. Xi Y#, Lin Y#, Guo W#, Wang X, Zhao H, Miao C, Liu W, Liu Y, Liu T, Luo Y, Fan W, Lin A, Chen Y, Sun Y, Ma Y, Niu X, Zhong C, Tan W, Zhou M, Su J*, Wu C*, Lin D*. Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma. Signal Transduction and Target Therapy, 2022;7:896–908. (IF=38.104)

3. Liu W#, Miao C#, Zhang S#, Liu Y, Niu X, Xi Y, Guo W, Chu J, Lin A, Liu H, Yang X, Chen X, Zhong C, Ma Y, Wang Y, Zhu S, Liu S, Tan W, Lin D*, Wu C*.VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance. Signal Transduction and Target Therapy, 2021;6:2906–2919. (IF=38.104)

4. Li R#, Di L#, Li J#, Fan W#, Liu Y, Guo W, Liu W, Liu L, Li Q, Chen L, Chen Y, Miao C, Liu H, Wang Y, Ma Y, Xu D, Lin D*, Huang Y*, Wang J*, Bai F*, Wu C* (2021). A body map of somatic mutagenesis in morphologically normal human tissues. Nature 2021;597:398–403. (IF=69.504)

5. Zhang J#, Bai R#, Li M#, Ye H, Wu C, Wang C, Li S, Tan L, Mai D, Li G, Pan L, Zheng Y, Su J, Ye Y, Fu Z, Zheng S, Zuo Z, Liu Z, Zhao Q, Che X, Xie D, Jia W, Zeng M, Tan W, Chen R*, Xu R*, Zheng J*, Lin D*. Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression. Nature Communications 2019;10:1858. (IF=12.121)

6. Zhao Y#, Wei L#, Shao M, Huang X, Chang J, Chang J, Chu J, Cui Q, Peng L, Lou Y, Tan W, Tan WL, Lin D*, Wu C*. BRCA1 associated protein increases invasiveness of esophageal squamous-cell carcinoma. Gastroenterology 2017;153:1304–19. (IF=18.392)

7. Zheng J#, Huang X, Tan W, Yu D, Du Z, Chang J, Wei L, Hang Y, Wang C, Che X, Zhou Y, Miao X, Jiang G, Yu X, Yong X, Cao G, Zou C, Li Z, Wang C, Cheung ST, Jia Y, Zheng X, Shen H, Wu C*, Lin D*.Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nature Genetics 2016;48:747–57. (IF=27.959)

8. Wu C#, Li D, Jia W, Hu Z, Zhou Y, Yu D, Tong T, Wang M, Lin D, Qiao Y, Zjou Y, Chang J, Zhai K, Wang M, Wei L, Tan W, Shen H, Zeng Y, Lin D*. Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma patients. Nature Genetics 2013;45:632–638. (IF=35.209)

9. Wu C#, Kraft P, Zhai K, Chang J, Zhao W, Li Y, Hu Z, He Z, Jia W, Abnet CC, Liang L, Hu N, Miao X, Zhou Y, Liu Z, Zhan Q, Liu Y, Qiao Y, Zhou Y, Jin G, Guo C, Lu C, Yang H, Fu J, Yu D, Freedman ND, Ding T, Tan W, Goldstein AM, Wu T, Shen H, Ke Y, Zeng Y, Chanock SJ, Taylor PR, Lin D*. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nature Genetics 2012;44:1090–1097. (IF=35.532)

10. Wu C#, Miao X, Huang L, Che C, Jiang G, Yu D, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X, Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Zhai K, Chang J, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Xu J, Tan W, Zhao P, Wu T, Wang C*, Lin D*. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nature Genetics 2012;44:62–66. (IF=35.532)