游雪甫，1966年生，籍贯江西丰城，抗感染药物药理学家，医药生物技术研究所研究员，博士生导师。1980年考入江西医学院医疗系专业，1985年获得医学学士学位。1987年在中国协和医科大学微生物与生化药学系攻读硕士学位，从事抗菌药物药理学研究。1993年升为助理研究员，1998年为副研究员，2004年为研究员，2009年为博士生导师，2020年为长聘教授。

抗耐药菌/超级细菌药物的发现与研发、细菌耐药/致病机制、抗菌药物的药效、药代、PK/PD评价。

1. Han Qiao#, Jie Yu, Xiukun Wang, Tongying Nie, Xinxin Hu, Xinyi Yang, Congran Li*, and Xuefu You*. Effect of Different Tolerable Levels of Constitutive mcr-1 Expression on Escherichia coli. Microbiol Spectr. 2022, accepted (IF=9.043)

2. Lang Sun#, Youwen Zhang, Tanxi Cai, Xue Li, Na Li, Zhensheng Xie, Fuquan Yang*, and Xuefu You*. CrrAB regulates PagP-mediated glycerophosphoglycerol palmitoylation in the outer membrane of Klebsiella pneumoniae. J Lipid Res. 2022 Jul 13:100251. doi:10.1016/j.jlr.2022.100251. Online ahead of print (IF =6.676)

3. Yun Lu#, Xinxin Hu, Jing Pang, Xiukun Wang, Guoqing Li, Congran Li, Xinyi Yang, and Xuefu You*. Parallel Reaction Monitoring Mass Spectrometry for Rapid and Accurate Identification of β-Lactamases Produced by Enterobacteriaceae. Front Microbiol. 2022 Jun 20;13:784628. doi:10.3389/fmicb. 2022.784628. eCollection 2022 (IF=6.064)

4. Yue Li#, Yifan Ouyang#, Han Wu#, Peng Wang, Yu Huang, Xue Li, Hongtong Chen, Yu Sun, Xinxin Hu, Xiukun Wang, Guoqing Li, Yun Lu, Congran Li, Xi Lu, Jing Pang, Tongying Nie, Xiaohong Sang, Luyao Dong, Wenting Dong, Jiandong Jiang, Ian C. Paterson, Xinyi Yang*, Wei Hong*, Hao Wang*, and Xuefu You*. The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur J Med Chem. 2022 Jan 15; 228:113979. doi: 10.1016/j.ejmech.2021.113979. Epub 2021 Nov 11. PMID: 34802838 (IF=7.088)

5. Lilan Sun#, Lang Sun, Xue Li, Xinxin Hu, Xiukun Wang, Tongying Nie, Youwen Zhang*, and Xuefu You*. A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae. Front Cell Infect Microbiol. 2022 Jan 5;11:809542. doi: 10.3389/fcimb.2021.809542. eCollection 2021.PMID: 35071055 (IF =6.073)

6. Yun Lu#, Xinxin Hu, Tongying Nie, Xinyi Yang, Congran Li, and Xuefu You*. Strategies for Rapid Identification of Acinetobacter baumannii Membrane Proteins and Polymyxin B's Effects. Front Cell Infect Microbiol. 2021 Sep 21;11:734578. doi: 10.3389/fcimb. 2021.734578. PMID: 34621692; PMCID: PMC8490878 (IF= 5.293)

7. Xue Li#, Lang Sun, Congran Li, Xinyi Yang, Xiukun Wang, Xinxin Hu, Tongying Nie, Youwen Zhang*, and Xuefu You*. The Attenuated Protective Effect of Outer Membrane Vesicles Produced by a mcr-1 Positive Strain on Colistin Sensitive Escherichia coli, Front Cell Infect Microbiol. 2021, 11: 701625 (IF=5.293)

8. Limin Dong#, Jing Pang, Xiukun Wang, Youwen Zhang, Guoqing Li, Xinxin Hu, Xinyi Yang, Chung-Dar Lu, Congran Li*,and Xuefu You*. Mechanism of pyocyanin abolishment caused by mvaT mvaU double knockout in Pseudomonas aeruginosa PAO1. Virulence. 2020,11(1): 57-67, DOI: 10.1080/21505594.2019.1708052 (IF=5.542)

9. Genzhu Wang#, Liang Li#, Xiukun Wang, Xue Li, Youwen Zhang, Jie Yu, Jiandong Jiang, Xuefu You*, and Yan Q Xiong*. Hypericin enhances β-lactam antibiotics activity through inhibition of sarA inMethicillin-Resistant Staphylococcus aureus. Acta Pharm Sin B. 2019;9(6):1174-1182. doi: 10.1016/j.apsb.2019.05.002 (IF=7.097)

10. Qing Wang#, Yuemeng Lv#, Jing Pang, Xue Li, Xi Lu, Xiukun Wang, Xinxin Hu, Tongying Nie, Xinyi Yang, Yan Q. Xiong, Jiandong Jiang, Congran Li*, and Xuefu You*. In vitro and in vivo Activity of D-Ser in Combination with β-lactam Antibiotics against Methicillin- Resistant Staphylococcus aureus. Acta Pharm Sin B. 2019;9(3): 496-504. doi: 10.1016/j.apsb.2019.01.017 (IF=7.097)