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药物研究所

个人简介

石建功,1964年生,籍贯甘肃渭源,天然药物化学专家,药物研究所研究员,博士生导师。1981年考入兰州医学院药学专业,1985年获学士学位。1987年在兰州医学院药学专业攻读硕士学位,从事中草药化学成分研究。1990年在兰州大学化学专业攻读博士学位,从事天然有机化学研究。作为博士后,先后于1993年在中国科学院兰州化学物理研究所、1995年在美国Illinois大学化学系、1997年在Puerto Rico大学化学系,开展天然产物化学研究。1998年获聘副研究员,1999年起任研究员。


主要研究方向

常用中药化学成分及其生物活性研究。重点开展常用中药多样性成分的系统分离、结构鉴定及其与药理学紧密结合的多模型药理活性筛选和评价,以及活性化合物的结构优化和合成研究。


代表性成果

1.Jingfang Zhang#, Xiaoqiang Lei, Yazi Wei, Hui Liu, Qinglan Guo*, Tiantai Zhang*, and Jiangong Shi*. Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii. Chin. Chem. Lett. 33(12):5047–50. (IF=8.455)

2. Xiaoqiang Lei#*, Juan Feng, Qinglan Guo, Chengbo Xu, and Jiangong Shi*. Base-promoted formal [3 + 2] cycloaddition of α‑halohydroxamates with carbon disulfide to synthesize polysubstituted rhodanines. Org. Lett. 24(15):2837–41. (IF=6.579)

3. Youzhe Chen#, Qinglan Guo, Chengbo Xu, Chenggen Zhu, Jianjun Zhang*, and Jiangong Shi*. (+)-/(−)-Angelignanine, a pair of neolignan enantiomers with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head. Chin. Chem. Lett.  32(5):1657−9. (IF=8.455)

4. Qinglan Guo#, Huan Xia#, Yuzhuo Wu, Shuai Shao, Chengbo Xu, Tiantai Zhang*, and Jiangong Shi*. Structure, property, biogenesis, and activity of diterpenoid alkaloids containing a sulfonic acid group from Aconitum carmichaelii. Acta Pharm. Sin. B 10(10):1954−65. (IF=11.614)

5. Qinglan Guo#, Dawei Li, Chengbo Xu, Chenggen Zhu, Ying Guo, Haibo Yu, Xiaoliang Wang, and Jiangong Shi*. Indole alkaloid glycosides with a 1ʹ-(phenyl)ethyl unit from Isatis indigotica leaves. Acta Pharm. Sin. B 10(5):895−902. (IF=11.614)

6. Yuzhuo Wu#, Shuai Shao#, Qinglan Guo, Chengbo Xu, Huan Xia, Tiantai Zhang*, and Jiangong Shi*. Aconicatisulfonines A and B, analgesic zwitterionic C20-diterpenoid alkaloids with a rearranged atisane skeleton from Aconitum carmichaelii. Org. Lett. 21(17):6850–4. (IF=6.091)

7. Minghua Chen#, Lishe Gan, Sheng Lin, Xiaoliang Wang, Li Li, Yuhuan Li, Chenggen Zhu, Yanan Wang, Bingya Jiang, Jiandong Jiang, Yongchun Yang, and Jiangong Shi*. Alkaloids from the root of Isatis indigotica. J. Nat. Prod. 75(6):1167–76. (IF=3.285)

8. Liang Xiong#, Chenggeng Zhu*, Yanru Li, Ye Tian, Sheng Lin, Shaopeng Yuan, Jinfeng Hu, Qi Hou, Naihong Chen, Yongchun Yang, and Jiangong Shi*. Lignans and neolignans from Sinocalamus affinis and their absolute configurations. J. Nat. Prod. 74(5):1188–200. (IF=3.128, C100)

9. Maoluo Gan#, Yanling Zhang, Sheng Lin, Mingtao Liu, Weixia Song, Jiachen Zi, Yongchun Yang, Xiaona Fan, Jiangong Shi*, Jinfeng Hu, Jiandong Sun, and Naihong Chen*. Glycosides from the root of Iodes cirrhosa. J. Nat. Prod. 71(4):647–54. (IF=2.843, C100)

10. Shunyan Mo#, Sujuan Wang, Guangxiong Zhou, Yongchun Yang, Yan Li, Xiaoguang Chen, and Jiangong Shi*. Phelligridins C−F: Cytotoxic pyrano[4,3-c][2]benzopyran-1, 6-dione and furo[3,2-c] pyran-4-one derivatives from the fungus Phellinus igniarius. J. Nat. Prod. 67(5):823–8. (IF=2.202, C100)