胡友财，1978年生，籍贯江西永丰，天然药物化学家，永利集团3044官网欢迎您药物研究所研究员，博士生导师。1996年考入沈阳药科大学化学制药专业，2000年获得学士学位。2000年在沈阳药科大学药物化学专业攻读硕士学位，从事活性天然产物化学合成研究。2005年在永利集团3044官网欢迎您攻读药物化学专业博士学位，从事天然药物化学研究。2010年进入美国德州大学西南医学中心进行博士后研究工作，主要从事海洋天然产物研究。2013年进入美国加州大学洛杉矶分校进行博士后研究工作，主要从事天然产物生物合成研究。2014年回国就职于药物研究所，聘为研究员。

基于合成生物学技术的天然药物化学研究：基因-化学-功能导向的活性天然产物发现；药用天然产物的形成机制与新药发现；天然药物合成生物学。

1. Daojiang Yan^#, Kunya Wang^#, Songlin Bai^#, Bingyu Liu^#, Jian Bai, Xiangbing Qi, and Youcai Hu*. Flavin-Dependent Monooxygenase-Mediated 1,2-Oxazine Construction via Meisenheimer Rearrangement in the Biosynthesis of Paeciloxazine. Journal of the American Chemical Society. 2022, 144(9): 4269-4276. (IF=16.383, F1000)

2. Beifen Zhong^#, Jun Wan^#, Changhui Shang^#, Jiajia Wen, Yujia Wang, Jian Bai, Shan Cen, Youcai Hu*. Biosynthesis of rumbrins and inspiration for discovery of HIV inhibitors. Acta Pharmaceutica Sinica B. 2022 https://doi.org/10.1016/j.apsb.2022.02.005. (IF=14.903)

3. Yalong Zhang, Jian Bai, Le Zhang, Chen Zhang, Bingyu Liu, and Youcai Hu*, Self-Resistance in the Biosynthesis of Fungal Macrolides Involving Cycles of Extracellular Oxidative Activation and Intracellular Reductive Inactivation. Angewandte Chemie International Edition. 2021, 60(12): 6639–6645. (IF=16.823, F1000)

4. Jiawang Liu^#, Anan Liu^# and Youcai Hu*, Enzymatic Dimerization in the Biosynthetic Pathway of Microbial Natural Products. Natural Product Reports. 2021, 38(8): 1469-1505. (IF=15.111)

5.Qian Wei^#, Jian Bai^#, Daojiang Yan, Xiuqi Bao, Wenting Li, Bingyu Liu, Dan Zhang, Xiangbing Qi, Dequan Yu, Youcai Hu*. Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products. Acta Pharmaceutica Sinica B. 2021, 11(2): 572-587. (IF=14.911)

6. Qibin Chen^#, Jie Gao^#, Cooper Jamieson, Jiawang Liu, Masao Ohashi, Jian Bai, Daojian Yan, Bingyu Liu, Yongsheng Che, Yanan Wang, K. N. Houk,* and Youcai Hu*. Enzymatic Intermolecular Hetero-Diels−Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes. Journal of the American Chemical Society. 2019, 141(36): 14052-14056. (IF=14.612, F1000)

7. Daojiang Yan^#, Qibin Chen^#, Jie Gao^#, Jian Bai, Bingyu Liu, Yalong Zhang, Le Zhang, Chen Zhang, Yi Zou, and Youcai Hu*, Complexity and Diversity Generation in the Biosynthesis of Fumiquinazoline-Related Peptidyl Alkaloids. Organic Letters, 2019, 21 (5): 1475-1479. (IF=6.091)

8. Shu-Shan Gao^#, Tao Zhang^#, Marc Garcia-Borràs, Yiu-Sun Hung, John M. Billingsley, K. N. Houk^*, Youcai Hu^*, and Yi Tang^*. Biosynthesis of Heptacyclic Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide. Journal of the American Chemical Society. 2018, 140(22): 6991-6997. (IF=14.695, F1000)

9. Jian Bai, Rong Mu, Man Dou, Daojiang Yan, Bingyu Liu, Qian Wei, Jun Wan, Yi Tang, Youcai Hu*. Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids. Acta Pharmaceutica Sinica B. 2018, 8(4): 687–697. (IF=5.808)

10.Jian Bai^#, Daojiang Yan^#, Tao Zhang, Yongzhi Guo, Yunbao Liu, Yi Zou, Mancheng Tang, Bingyu Liu, Qiong Wu, Shishan Yu*, Yi Tang*, and Youcai Hu*. A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angewandte Chemie International Edition. 2017, 56(17): 4782-4786. (IF=12.102, F1000)