李平平，1978年生，籍贯吉林德惠，药理学家，永利集团3044官网欢迎您药物研究所研究员，博士生导师。1996年考入中国药科大学药理专业，2001年获得学士学位。2001年在中国协和医科大学药物研究所药理专业攻读博士学位，从事糖尿病研究。2006年进入美国加州大学圣迭戈分校进行博士后研究工作，主要研究慢性炎症与肥胖和糖尿病。 2013年在美国加州大学圣迭戈分校升为助理教授。2015年在永利集团3044官网欢迎您药物研究所任研究员。

慢性炎症、胰岛素抵抗及胰岛素分泌的分子机制；肥胖、脂肪肝、2型糖尿病及癌症等代谢性疾病的发病机制、新药靶发现与鉴定及新药研发。

1. Liu X#, Wang K#, Wang L, Kong L, Hou S, Wan Y, Ma C, Chen J, Xing X, Xing C, Jiang Q, Zhao Q, Cui B, Huang Z*, Li P*. Hepatocyte Ltb4r1 promotes NAFLD development in obesity. Hepatology. 2022 Aug 5. doi: 10.1002/hep.32708. (IF=17.298)

2. Ying L#, Wang L#, Guo K#, Hou Y#, Li N, Wang S, Liu X, Zhao Q, Zhou J, Zhao L, Niu J, Chen C, Song L, Hou S, Kong L, Li X, Ren J*, Li P*, Mohammadi M*, Huang Z*. Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects. Nat Commun. 2021 12(1):7256. (IF=14.919)

3. Li PP#,*, Liu SN#, Lu M#, Bandyopadhyay G, Oh D, Imamura T, Johnson, A.M.F., Sears D, Shen ZF, Cui B, Kong LJ, Hou SC, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM*. Hematopoietic-derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell 2016. 167(4):973-984.e12 (IF=30.41)

4. Li P#,*, Oh DY#, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A,Chung H, Mayoral R, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM*. LTB4promotes insulin resistance in obese mice by acting on macrophages, hepatocytesand myocytes. Nat Med. 2015; 21(3): 239-47. (IF=30.357, C100)

5. Li, P. #, Spann, N.#, Kaikkonen, M., Lu, M., Oh, D., Fox, J., Bandyopadhyay, G., Talukdar, S., Xu, J., Lagakos, W., Patsouris, D., Armando, A., Quehenberger, O., Dennis, E., Watkins, S., Auwerx, J., Glass, C.*, Olefsky, J*.  NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids.  Cell 2013; 155, 200-214. (IF=33.116)

6. Baeza-Raja B#, Li PP#, D. Sachs B, Davalos D, Eirini Vagena, Schachtrup C, Loucks FA, Sikorski S, Helmrick M, Le Moan N, Bridges D, Tsigelny I, Baron LJ, Wynshaw-Boris. Anthony, Miriam Scadeng, Saltiel AR, Olefsky JM, Akassoglou K*: p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A 2012; 109(15):5838-43 (IF=9.737, F1000)

7. Li PP#, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM*: Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity. Cell 2011;147:815-826. (IF=32.403)

8.Lee YS#, Li PP#, Huh JY#, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB*: Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 2011;60:2474-2483. (IF=8.286, C100, ESI).

9. Li PP#, Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM*: Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem 2010;285:15333-15345. (IF=5.476, C100)

10. Patsouris D#, Li PP#, Thapar D, Chapman J, Olefsky JM, Neels JG*: Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 2008;8:301-309. (IF=16.107, C100)