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阜外医院

个人简介

蔡军,1975年生,籍贯湖北荆州,永利集团3044官网欢迎您阜外医院主任医师,博士生导师。1995年考入同济医科大学临床医学专业,2000年获得学士学位。2001年在武汉大学内科学专业攻读博士学位,从事心血管内科研究。2007年进入哈佛医学院麻省总医院进行博士后研究工作,主要研究心肌重构机制。2009年为副主任医师,2012年为主任医师。


主要研究方向

围绕高血压人群防治和发病机制开展系列创新性研究。以血管发育、重构相关易感基因为核心,肠道菌群稳态失调为切入点,通过新一代组学技术,揭示高血压病因,并展开临床试验,为高血压预防和干预提供证据和理论基础。


代表性成果

1. Fan L #, Chen J#, Pan L#, Xin X#, Geng B, Yang L, Wang Q, Ma W, Lou Y, Bian J, Cui X, Li J, Wang L, Chen Z, Wang W, Cui C, Li S, Gao Q, Song Q, Deng Y, Fan J, Yu J, Zhang H*, Li Y*, Cai J*, Alterations of gut microbiome, metabolome and lipidome in Takayasu arteritis. Arthritis & Rheumatology. 2022. Accepted (IF=15.483)

2. Chen Z#, Ouyang C#, Zhang H, Gu Y, Deng Y, Du C, Cui C, Li S, Wang W, Kong W, Chen J#, Cai J*, Geng B*. Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy.Autophagy. 2022; 28;1-18.(IF=16.016)

3. Liu X#, Chen Z#, Li S#, Jin L, Cui X, Cui C, Deng Y, Gao Q, Fan L, Niu Y, Wang W, Cui C, Zhong J, Cui Q*, Geng B*, Cai J*.Pre-miRNA Hsa-Let-7a-2: a Novel Intracellular Partner of Angiotensin II Type 2 Receptor Negatively Regulating its Signals.Int J Biol Sci. 2022;18(8):3237-3250. (IF=10.750)

4. Zhang W#*, Zhang S#, Deng Y#, Wu S#, Ren J#, Sun G#, Yang J#, Jiang Y#, Xu X#, Wang TD#, Chen Y#, Li Y, Yao L, Li D, Wang L, Shen X, Yin X, Liu W, Zhou X, Zhu B, Guo Z, Liu H, Chen X, Feng Y, Tian G, Gao X, Kario K, Cai J*; STEP Study Group.Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension. N EngI J Med.2021;385(14): 1268-1279. (IF=91.245)

5. Song X#, Zou X#, Ge W, Hou C, Cao Z, Zhao H, Zhang T, Jin L, Fu Y, Kong W, Yan C, Cai J*, Wang J*. Blocking FcγRIIB in Smooth Muscle Cells Reduces Hypertension.Circ Rec. 2021;129(2):308-325.(IF=23.213)

6. Jin L#, Shi X, Yang J, Zhao Y, Xue L*, Xu L*, Cai J*.Gut microbes in cardiovascular diseases and their potential therapeutic applications.Protein Cell. 2021;12(5): 346–359.(IF=14.870)

7. Cui C#, Fan J#, Zeng Q#, Cai J#, Chen Y, Chen Z, Wang W, Li SY, Cui Q, Yang J, Tang C, Xu G, Cai J*, Geng B*.CD4+ T-Cell Endogenous Cystathionine γ Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation.Circulation. 2020;142(18):1752-1769.(IF=29.690)

8. Zhou X#, Li J#, Guo J#, Geng B, Ji W, Zhao Q, Li J, Liu X, Liu J, Guo Z, Cai W, Ma Y, Ren D, Miao J, Chen S, Zhang Z, Chen J, Zhong J, Liu W, Zou M, Li Y*, Cai J*. Gut-dependent microbial translocation induces inflammation and cardiovascular events after st-elevation myocardial infarction. Microbiome. 2018;6:66 (IF=10.465)

9. Jin L#, Lin X#, Yang L#, Fan X, Wang W, Li S, Li J, Liu X, Bao M, Cui X, Yang J, Cui Q, Geng B, Cai J*. AK098656, a Novel Vascular Smooth Muscle Cell-Dominant Long Noncoding RNA, Promotes Hypertension.Hypertension.2018; 71(2):262-272.(IF=10.190)

10. Li J#, Zhao F#, Wang Y#, Chen J#, Tao J#, Tian G, Wu S, Liu W, Cui Q, Geng B, Zhang W, Weldon R, Auguste K, Yang L, Liu X, Chen L, Yang X*, Zhu B*, Cai J*.Gut microbiota dysbiosis contributes to the development of hypertension.Microbiome.2017;5(14):66. (IF=9.133, C100)